Tremela fungus polysaccharides can significantly reduce blood glucose levels in diabetic miceus caused by tetraoxopyrimidine and streptochlorin-induced diabetic mice, increase serum insulin levels, and reduce water intake in diabetic mice. The receptor activated by mouse peroxisome proliferative factor is γ (peroxisome proliferators-activated receptor-γ，PPAR-γ) a key regulator of insulin action, and the expression of PPAR-γmRNA and plasma PPAR-γ protein was significantly increased when mice were fed with tremela extracellular polysaccharides for 52 days. This suggests that tremella polysaccharides may lower blood sugar and improve insulin sensitivity by regulating PPAR-γ-mediated lipid metabolism.
Tremela polysaccharides reduce blood lipids by inhibiting the absorption of lipids in the intestines of rats and mice, and the mechanism may be because the polysaccharides of tremella fungus are saturated with hydroxyl groups, carboxyl groups and amino groups, which have strong hydrophilicity and adsorb lipids and cholesterol to prevent the absorption of lipids. At the same time, silver fungus polysaccharide can combine with bile acid, promote bile acid discharge, block the liver and intestinal circulation, so that cholesterol metabolism can be carried out smoothly in one direction and reduce blood lipids. [1]
[Reference].
[1] WEI Guo-Zhi, LI Guo-Guang, JIN Mei-Hong. Research progress on polysaccharides of silver fungus [J]. Flavors and Cosmetics, 2008(2):33-35.
Post time: Oct-20-2022